2010 Fiscal Year Final Research Report
Protective effect of docosahexaenoic acid (DHA) on celebral ischemia.
| Project/Area Number |
20580222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Miyagi University |
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Principal Investigator |
NISHIKAWA Masazumi Miyagi University, 食産業学部, 教授 (90404839)
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| Co-Investigator(Kenkyū-buntansha) |
HISHINUMA Takanori 東北大学, 薬学研究科, 教授 (20199003)
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| Co-Investigator(Renkei-kenkyūsha) |
MURAYAMA Koichiro 埼玉医科大学, 医学部, 准教授 (00219891)
FUJIWARA Michihiro 福岡大学, 薬学部, 教授 (10091331)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脂質 / 水産学 / 神経科学 / 生理活性 / 栄養学 |
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| Research Abstract |
We investigated the neuroprotective efficacy of docosahexaenoic acid (DHA), the most abundant omega-3 fatty acid in the mammalian brain and fish, in rats using single and repeated celebral ischemia models, middle cerebral artery occlusion model, ibotenic acid-induced amnesic model. DHA, given between 21～30 days before ischemia, improved the memory and reduced infarct volume. From these results, it appears that DHA could provide neuroprotective activity and improve the spatial memory impaired by ischemia.
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