2010 Fiscal Year Final Research Report
Release of purines and its mechanisms under ischemic conditions in spinal cord
| Project/Area Number |
20580317
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
OTSUGURO Ken-ichi Hokkaido University, 大学院・獣医学研究科, 准教授 (40344494)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アデノシン / 脊髄 / 新生ラット / 反射電位 / 低酸素 / アシドーシス / 虚血 |
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| Research Abstract |
It is well-known that hypoxia and acidosis significantly influence neuronal functions under ischemic conditions. In this study, an electrical activity of spinal neuronal pathways and extracellular purine concentration were measured. Hypoxia and acidosis released not only adenosine but also inosine from the spinal cord, and adenosine suppressed the neuronal activities via adenosine A1 receptors. In addition, the influence of hypoxia largely depended on age, temperature and neuronal pathways. It is suggested that adenosine plays an important role in this phenomenon.
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