2010 Fiscal Year Final Research Report
Age-dependant NO production and its regulation involved in the uterus and placenta of pregnant rat
| Project/Area Number |
20580329
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Azabu University |
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Principal Investigator |
TAKIZAWA Tatsuya Azabu University, 獣医学部, 教授 (00247305)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Kazuaki 麻布大学, 獣医学部, 准教授 (50345873)
MORITA Hidetoshi 麻布大学, 獣医学部, 教授 (70257294)
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| Research Collaborator |
SUZUKI Takehito 麻布大学, 獣医学部, 講師 (90532052)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 動物 / 発生・分化 / スピントラップ・EPR / 生体分子 |
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| Research Abstract |
NO production and its regulation involved in the uterine endometrium and placenta were examined in pregnant rat. NO productions level peak on gestational day 17.5 (GD17.5)and GD15.5 in the endometrium and placenta, respectively. These NO productions were mainly derived from induced NO synthase in the tissues. Inhibitor of NO production caused apoptosis through typical apoptotic signals in the endometriumu on GD17.5, suggesting that an NO peak in the endometrium is essential to cell survival and the maintenance of uterine formation.
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