2010 Fiscal Year Final Research Report
Role of the TGF-β family and Mitf during osteoclastogenesis
| Project/Area Number |
20580330
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Azabu University |
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Principal Investigator |
MURAKAMI Masaru Azabu University, 獣医学部, 教授 (80271360)
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| Co-Investigator(Renkei-kenkyūsha) |
FUNABA Masayuki 京都大学, 農学研究科, 准教授 (40238655)
NISHINO Yoshii 京都産業大学, 総合生命科学部, 准教授 (00271544)
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| Project Period (FY) |
2008 – 2010
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| Keywords | TGF-βファミリー / Mitf / 遺伝子発現制御 / 破骨細胞分化 / シグナル伝達 |
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| Research Abstract |
We explored the role of TGF-β family that regulates a broad range of biological processes and Mitf that is a tissue-specific transcription factor, in the process of RANKL-induced osteoclast formation. This study indicates that Mitf-E plays a crucial role in osteoclastogenesis, and that the TGF-β family positively regulates the expression of Mitf-E as well as osteoclast marker genes. Stimulatory activity of the TGF-β family on osteoclastogenesis may be partly elicited through up-regulation of Mitf-E.
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