2010 Fiscal Year Final Research Report
Effect of hypertension and hyperlipidemia on diabetic peripheral neuropathy
| Project/Area Number |
20580332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Setsunan University |
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Principal Investigator |
OZAKI Kiyokazu Setsunan University, 薬学部, 講師 (40268496)
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| Co-Investigator(Kenkyū-buntansha) |
NARAMA Isao 摂南大学, 薬学部, 教授 (80268490)
MATSUURA Tetsuro 摂南大学, 薬学部, 講師 (20268494)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 末梢神経 / 糖尿病 / 高血圧 / 高脂血症 |
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| Research Abstract |
To investigate the effects of mild hypertension after unilateral nephrectomy, and hyperlipidemia induced by feeding of high-fat diet on diabetic peripheral neuropathy, we examined the peripheral nerves of diabetic WBN/Kob and ZDF rats, Mild hypertension and hypertriglyceridemia were induced in both animals. However, nerve conduction velocity and morphological lesions of peripheral nerves were comparable in all groups. These findings indicate that unilateral nephrectomy and hypertriglyceridemia have little effect on diabetic peripheral neuropathy.
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