2010 Fiscal Year Final Research Report

Regulation of allergic inflammation by TGF-b superfamily proteins

Research Project

Project/Area Number	20580334
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	OGAWA KENJI The Institute of Physical and Chemical Research, 分子リガンド探索研究チーム, 専任研究員 (50251418)
Project Period (FY)	2008 – 2010
Keywords	Activin A / TGF-β / Bリンパ球 / マクロファージ / IgA / MMP-9 / Toll-like receptors
Research Abstract	In order to determine the roles of the TGF-β superfamily proteins in allergic inflammation, we studied the effects of activin A and TGF-β1 in mouse macrophages and B lymphocytes. Production of activin A was increased, while the expression of TGF-β1 was decreased in macrophages upon activation. Pretreatment with activin A significantly increased IgG, but not IgA and IgM, production, while TGF-β1 significantly enhanced IgA and suppressed IgM production in B cells. The functions of activin A partly overlap but are clearly distinct from that of TGF-β1 in macrophages and B cells, indicating that these two factors have distinct functions in allergic inflammation.

(5 results)