2010 Fiscal Year Final Research Report
Analysis for the mechanism of genome stability by the TREX complex, which has an essential role for the mRNA maturation in the nucleus.
| Project/Area Number |
20580370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Kyoto University |
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Principal Investigator |
MASUDA Seiji Kyoto University, 大学院・生命科学研究科, 准教授 (20260614)
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| Co-Investigator(Kenkyū-buntansha) |
MOMMA Keiko 京都文教大学, 人間学部, 准教授 (70397561)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 分子間相互作用 |
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| Research Abstract |
The TREX complex has an essential function in mRNA biogenesis. Here I have studied the function of UAP56 and URH49, whish are the component of the TREX complex, in view of the relationship between mRNA biogenesis and genome stability. Fragmentation from chromosome DNA was observed when URH49 was knocked down rather than that UAP56 was. This phenotype was rescued by the forced expression of URH49, RNaseH, SF2 or RNPS1. These results suggest that the TREX complex functions to regulate the interaction of nascent RNA with genomic DNA to prevent the genome instability.
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[Journal Article] The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.2010
Author(s)
Yamazaki T., Fujiwara N., Yukinaga H., Ebisuya M., Shiki T., Kurihara T., Kioka N., Kambe K., Nagao M., Nishida E., Masuda S.
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Journal Title
Mol. Biol. Cell. 21
Pages: 2953-2965
Peer Reviewed
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