2010 Fiscal Year Final Research Report
Synthetic Studies toward Kinamycin-Jadomycin Antibiotics
| Project/Area Number |
20590002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
KUMAMOTO Takuya Musashino University, 薬学研究所, 教授 (50292678)
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| Project Period (FY) |
2008 – 2010
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| Keywords | キナマイシン / ロマイビチシン / ジャドマイシン / グアニジン / 二量化反応 |
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| Research Abstract |
Total syntheses of prekinamycin and jadomycin A were achieved via "naphthalene route", Suzuki-Miyaura coupling of bromonaphthalene unit as AB ring and phenylboronic acid as D ring part. C ring formation of AB-D ring unit followed by diazotization lead to the synthesis of the former compound. The latter was synthesized by introduction of isoleucine and deprotection. The basic carbon skeleton of kinamycins was also achieved by introduction of oxygen functionality on D ring of same synthetic intermediate of prekinamycin.
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