2010 Fiscal Year Final Research Report
Study of encephalopathy inducing constituent in Pleurocybella porrigens
Project/Area Number |
20590004
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical pharmacy
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Research Institution | Kanazawa University |
Principal Investigator |
OHTA Tomihisa Kanazawa University, 薬学系, 教授 (50108560)
|
Project Period (FY) |
2008 – 2010
|
Keywords | 生物活性物質 |
Research Abstract |
This study was focused on the supposition that Angel Wing (Pleurocybella porrigens) brain disorder was based on plural toxic causes. The refinement and the structural analysis of the peptidyl polysialic analogues having internal organs disorder characteristics and inflammatory nature showed that N-glycolyl neuraminic acid (NeuGc) indicating the antigenicity was specifically included in the glycoprotein of the Angel Wing. On the other hand, the structure of sphingoglycolipid A was determined and synthesized. Sphingoglycolipid A was presumed on impaired characteristics to the nervous system and intestinal epithelia.
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[Journal Article]2009
Author(s)
T.Takata, T.Hasegawa, T.Tatsuno, J.Date, Y.Ishigaki, Y.Nakamura, N.Tomosugid, F.Takano, T.Ohta
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Journal Title
J.Health Science 55
Pages: 373-379
Peer Reviewed
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