2010 Fiscal Year Final Research Report
Preparation of novel beta-lactam derivatives using efficient leaving group
| Project/Area Number |
20590005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Gifu University |
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Principal Investigator |
KOKETSU Mamoru Gifu University, 工学部, 教授 (50178208)
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| Project Period (FY) |
2008 – 2010
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| Keywords | β-ラクタム / セレン / グラブズ試薬 / ヘテロ環化合物 |
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| Research Abstract |
Recently, there is a tremendous amount of preparation of selenium-containing compounds because of not only interesting reactivity but also biological activity. In this study, we have developed novel selenating reagent prepared by the reaction of potassium p-methylselenobenzoate with 2-bromoethyl-trimethylsilane. Novel selenium-containing β-lactams were efficiently prepared by the reaction of alkenes and alkynes with Grubbs 2^<nd> gen. catalyst. And also the β-lactams were obtained via the regioselective iodocyclization reaction from corresponding alkyne- and alkane-selenoureas. The synthesis of higher-membered selenium heterocycles such as seven- and eight-membered selenium-containing heterocycles has hardly been reported yet.
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