2010 Fiscal Year Final Research Report
Development of novel chemical libraries for drug discovery based on the oligosaccharides moieties of significant bio-active glycosides.
| Project/Area Number |
20590008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
IKEDA Tsuyoshi Kumamoto University, 大学院・生命科学研究部, 准教授 (80295138)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 糖鎖 / ケミカルバイオロジー / 癌 / 生活習慣病植物 |
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| Research Abstract |
In tomato plant bodies including leaves and stems, a steroidal alkaloid "tomatine" is the major ingredient of all. We prepared the propargyl lycotetraoside from the tomatine by using end-glycosidase "tomatinase" in the presence of propargyl alcohol. We applied to synthesize several lycotetraosyl derivatives coupled with an acetylene group in the propargyl lycotetraoside and azide groups in aglycone parts. The synthesis procedure is very simple and effective to get many kinds of lycotetraosyl derivatives having triazole ring without protection of hydroxyl group in lycotetraosides.
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[Journal Article] Onionin A from Allium cepa Inhibits Macrophage Activation.2010
Author(s)
El-Aasr M., Fujiwara Y., Takeya M., Ikeda T., Tsukamoto S., Ono M., Nakano D., Okawa M., Kinjo J., Yoshimitsu H., Nohara T.
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Journal Title
J.Nat.Prod. 73
Pages: 1306-1308
Peer Reviewed
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