2010 Fiscal Year Final Research Report
Development of nickel-catalyzed Mizoroki-Heck reactions
| Project/Area Number |
20590009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
IKEDA Shin-Ichi Nagoya City University, 大学院・薬学研究科, 准教授 (90254309)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ニッケル / 溝呂木-ヘック反応 / ドミノ反応 / β-酸素脱離 / 切断 |
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| Research Abstract |
Ni-catalyzed Mizoroki-Heck-type reaction with alkyne-tethered allyl alcohols which included selective β-elimination of a C-OH bond was accomplished. The β-OH elimination proceeded in preference to β-H elimination for a (σ-alkyl) nickel intermediate which has both H and OH on the same β-carbon to the Ni center.
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