2010 Fiscal Year Final Research Report
Hypoglycemic Effects of Compounds from Crude Drugs focused on the participation of Monoamine Neurotransmitters in Blood Glucose Regulation
| Project/Area Number |
20590011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Showa University |
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Principal Investigator |
HORI Yumiko Showa University, 薬学部, 講師 (60317584)
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| Co-Investigator(Kenkyū-buntansha) |
TORIIZUKA Kazuo 昭和大学, 薬学部, 教授 (60135035)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生姜 / 乾姜 / スルホン化誘導体 / 血糖値 / 神経伝達物質 |
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| Research Abstract |
The sulfonated derivatives from Shokyo and Kankyo have a glucose-lowering effect on loading sugar, which may be based on inhibition of the activity of saccharide hydrolyzing enzyme. Also, the repeated administration of 6-gingesulfonic acid for five weeks showed continuous hypoglycemic effects throughout the experimental periods in KK-A^y mice. Concomitantly, the hypoglycemic effects of 6-GS were correlated with the increased brain serotonin levels. These findings suggest that serum glucose concentrations influence on the brain monoamine neurotransmitters metabolism in KK-A^y mice.
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