2011 Fiscal Year Final Research Report
Study on crude drugs regulating adipocyte differentiation
| Project/Area Number |
20590016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2011
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| Keywords | 生薬 / 天然物化学 |
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| Research Abstract |
Research was carried out for some herbal medicines using macrophage-like cell RAW264.7 and mouse 3T3-L1 preadipocyte. We found that many components isolated from Mulberry root bark, leaf of sea buckthorn, cassia seed, and flower of Albizia julibrissin by the bio-assay guided separation. These compounds inhibited adipogenesis in 3T3-L1 preadipocytes and NO production over the course of macrophage activation. On the other hand, the component isolated from peach flower showed the differentiation promotion of adipocyte and the update serection of adiponectin.
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