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2010 Fiscal Year Final Research Report

Development of new antifungal drugs isolated from fungal sources in order to overcome of deep-seated mycosis

Research Project

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Project/Area Number 20590017
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionHoshi University

Principal Investigator

KAWAI Kenichi  Hoshi University, 薬学部, 教授 (30061295)

Co-Investigator(Kenkyū-buntansha) HOSOE Tomoo  星薬科大学, 薬学部, 准教授 (10287849)
ITABASHI Taeshi  星薬科大学, 薬学部, 助手 (20350225)
Project Period (FY) 2008 – 2010
Keywords抗真菌剤 / 深在性真菌症 / 新規分離真菌
Research Abstract

The new antifungal drugs will be expected, in consideration of the recent slightly increasing of the deep-seated mycoses. The extracts of newly isolated fungal strains, which had the antifungal activities, were purified by various chromatography and then about 20 new compounds were isolated and determined their structures. The possibility of the antifungal drugs for the above compounds will be tested.

  • Research Products

    (19 results)

All 2011 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (14 results)

  • [Journal Article] A new antifungal yellow pigment from Aspergillus nishimurae2011

    • Author(s)
      Tomoo Hosoe, Nobuaki Mori, Kumi Kamano, Takeshi Itabashi, Kayoko Takizawa, Takashi Yaguchi, Ken-ichi Kawai
    • Journal Title

      J.Antibiotics 64(2)

      Pages: 211-212

    • Peer Reviewed
  • [Journal Article] Novofumigatamide, new cyclic tripeptide from Aspergillus novofumigatus2010

    • Author(s)
      Kazuki Ishikawa, Tomoo Hosoe, Takeshi Itabashi, Kayoko Takizawa, Takashi Yaguchi, Ken-ichi Kawai
    • Journal Title

      Heterocycles 81(9)

      Pages: 2143-2148

    • Peer Reviewed
  • [Journal Article] Novoamauromine and ent-cycloechinulin : Two new diketopiperazine derivatives from Aspergillus novofumigatus2010

    • Author(s)
      Kazuki Ishikawa, Tomoo Hosoe, Takeshi Itabashi, Daigo Wakana, Kayoko Takizawa, Takashi Yaguchi, Ken-ichi Kawai
    • Journal Title

      Chem.Pharm.Bull. 58(5)

      Pages: 717-719

    • Peer Reviewed
  • [Journal Article] The cytotoxic and antifungal activity of two new sesquiterpenes, malfilanol A and B, derived from Malbranchea filamentosa2009

    • Author(s)
      Daigo Wakana, Tomoo Hosoe, Hiroshi Wachi, Takeshi Itabashi, Kazutaka Fukushima, Takashi Yaguchi, Ken-ichi Kawai
    • Journal Title

      J.Antibiotics 62(4)

      Pages: 217-219

    • Peer Reviewed
  • [Journal Article] A new indoloditerpene derivative, penijanthine A, from Penicillium janthinellum2009

    • Author(s)
      Takeshi Itabashi, Tomoo Hosoe, Daigo Wakana, Kazutaka Fukushima, Kayoko Takizawa, Takashi Yaguchi, Kaoru Okada, Galba Maria de Campos Takaki, Ken-ichi Kawai
    • Journal Title

      J.Natural Med. 63(1)

      Pages: 96-99

    • Peer Reviewed
  • [Presentation] Aspergillus novofumigatus CBS117520から単離された新規環状テトラペプチドおよびメロテルペノイド2011

    • Author(s)
      石川和樹、板橋武史、細江智夫、滝澤香代子、矢口貴志、福島和貴、河合賢一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
  • [Presentation] Neosartorya sp.A159株の産生する新規meroterpeneおよびbenzodiazepine誘導体2011

    • Author(s)
      板橋武史、細江智夫、滝澤香代子、矢口貴志、河合賢一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
  • [Presentation] Emericella sp.IFM57991より得られた新規farnesylisobenzofurane誘導体2011

    • Author(s)
      齊藤哲也、板橋武史、細江智夫、滝澤香代子、矢口貴志、福島和貴、河合賢一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
  • [Presentation] Beauveria bassiana IFM59745株の成分検索2011

    • Author(s)
      森本重輝、齊藤哲也、石川和樹、板橋武史、細江智夫、滝澤香代子、矢口貴志、河合賢一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
  • [Presentation] Emericella sp.IFM57991より得られた新規isobenzofuranおよびisobenzofuranone誘導体 第2号2010

    • Author(s)
      齊藤哲也、板橋武史、細江智夫、河合賢一、滝澤香代子、矢口貴志、福島和貴
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
  • [Presentation] Aspergillus novofumigatusから単離された新規メロテルペノイド2010

    • Author(s)
      石川和樹、細江智夫、板橋武史、河合賢一、滝澤香代子。矢口貴志、福島和貴
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
  • [Presentation] Aspergillus novofumigatusより得られる新規環状ペプチド及びベンゾジアゼピン誘導体の構造2009

    • Author(s)
      石川和樹、板橋武史、細江智夫、河合賢一、滝澤香代子、矢口貴志、福島和貴、若菜大悟、合田幸広
    • Organizer
      日本生薬学会第56回年会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-03
  • [Presentation] Emericella sp.IFM57991より得られた新規isobenzofuranおよびisobenzofuranone誘導体2009

    • Author(s)
      齊藤哲也、板橋武史、細江智夫、河合賢一、滝澤香代子、矢口貴志、福島和貴
    • Organizer
      日本生薬学会第56回年会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-03
  • [Presentation] Aspergillus novofumigatusの産生する新規diketopiperazineおよびditerpene誘導体2009

    • Author(s)
      石川和樹、若菜大悟、板橋武史、細江智夫、滝澤香代子。矢口貴志、河合賢一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
  • [Presentation] Neosartorya sp.A159株の産生するジケトピペラジン化合物の立体化学2009

    • Author(s)
      板橋武史、細江智夫、滝澤香代子。矢口貴志、河合賢一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
  • [Presentation] Zebrafishに対する色素形成抑制作用を指標とした真菌由来"美白効果"物質の探索2009

    • Author(s)
      二宮早也夏、細江智夫、板橋武史、河合賢一、野中里紗、輪千浩史、瀬山義幸、矢口貴志、滝澤香代子、福島和貴
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
  • [Presentation] Malbranchea gypseaの成分検索2008

    • Author(s)
      笠原宏之、細江智夫、板橋武史、河合賢一、滝澤香代子、福島和貴
    • Organizer
      日本生薬学会第55回年会
    • Place of Presentation
      長崎
    • Year and Date
      2008-09-20
  • [Presentation] Neosartorya属菌の"新種"とプロファイルされたA159菌株の成分研究2008

    • Author(s)
      板橋武史、細江智夫、河合賢一、矢口貴志
    • Organizer
      日本生薬学会第55回年会
    • Place of Presentation
      長崎
    • Year and Date
      2008-09-19
  • [Presentation] Malbranchea filamentosaから得られる新規セスキテルペンの構造2008

    • Author(s)
      若菜大悟、細江智夫、板橋武史、矢口貴志、滝澤香代子、福島和貴、河合賢一
    • Organizer
      日本生薬学会第55回年会
    • Place of Presentation
      長崎
    • Year and Date
      2008-09-19

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Published: 2012-01-26   Modified: 2016-04-21  

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