2010 Fiscal Year Final Research Report
Development of effective method for an introduction of decarboxylative nucleophile in the synthesis of indole derivative and its application to solid phase catalytic reaction
| Project/Area Number |
20590024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
MIKI Yasuyoshi Kinki University, 薬学部, 教授 (40122113)
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| Co-Investigator(Kenkyū-buntansha) |
HAMAMOTO Hiromi 近畿大学, 薬学部, 講師 (40365896)
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| Project Period (FY) |
2008 – 2010
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| Research Abstract |
Reaction of indole-2,3-dicarboxylic acids with hypervalent iodine reagent and lithium halide gave the corresponding 2,3-dihaloindoles via decarboxylative halogenation. Pyrrolophenanthridone alkaloids were also synthesized via decarboxylative halogenation and reduction of the iodo compound. In a similar manner, 4-methoxybenzoic acid derivatives were also converted to 4-iodoanisoles.
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Research Products
(35 results)
