2010 Fiscal Year Final Research Report
A thoroughgoing investigation of structure of chondroitin sulfate stimulating on immunosystem.
| Project/Area Number |
20590032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
TOIDA Toshihiko Chiba University, 大学院・薬学研究院, 教授 (60163945)
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| Project Period (FY) |
2008 – 2010
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| Keywords | コンドロイチン硫酸オリゴ糖ライブラリー / 免疫系 / 経口投与 / サイトカイン産生 |
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| Research Abstract |
Commercially available chondroitin sulfate was depolymerized by photolytic degradation system using titanium dioxide under 370～430 nm, and each oligosaccharide has been isolated and characterized by chromatographic and instrumentational techniques. Additionally, the purified chondroitin sulfate oligosaccharides were chemically over sulfonated using sulfur trioxide-pyridine complex and supplied for establishment of chondroitin sulfate oligomer library. Furthermore, these oligosaccharides were applied for the investigation of immune stimulating effects of chondroitin sulfate administered orally and found the exact size of oligosaccharide which is able to be absorbed through digestive system of mice.
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