2010 Fiscal Year Final Research Report
Development and application of determination methods of salivary hormones for noninvasive diagnosis of endocrine disorders
| Project/Area Number |
20590034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
HIGASHI Tatsuya Kanazawa University, 薬学部, 准教授 (90272963)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 唾液 / ホルモン検査 / 無侵襲 / 高速液体クロマトグラフィー-タンデム質量分析 / 分析科学 |
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| Research Abstract |
Saliva has recently been attracting attention as a noninvasive tool in clinical examinations. In this study, highly sensitive and specific liquid chromatography?electrospray ionization-tandem mass spectrometry methods were developed for the determination of low-molecular weight hormones and related compounds in saliva. For some compounds, novel derivatization procedures were developed to enhance their detection responses. The developed methods were useful in the diagnosis and treatment for several diseases and deficiencies, such as congenital adrenal hyperplasia, vitamin D deficiency, late-onset hypogonadism and Graves disease.
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Research Products
(17 results)
