2010 Fiscal Year Final Research Report
Development of rapid analysis method of drugs of abuse used for forensic science and clinical chemistry
| Project/Area Number |
20590043
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
SAITO Koichi Hoshi University, 薬学部・薬品分析化学教室, 准教授 (40386347)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 乱用薬物 / 法科学 / LC / TOF-MS / 固相分散抽出法 / 遠心ろ過フィルター |
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| Research Abstract |
In this study, determination of abused drugs such as MDMA, TFMPP, and related illegal drugs, and psychoactive drugs such as benzodiazepines, methylphenidate and methamphetamine has been developed by liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS), which is able to measure accurate mass with high sensitivity and high accuracy. Furthermore, a new pretreatment method so-called solid-phase dispersive extraction (SPDE) has been also developed for sample purification. In addition, a novel apparatus named a centrifugal filtration filter unit was invented for the purpose of simple and easy operation of the SPDE method.
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