2010 Fiscal Year Final Research Report
Development and application of the high-throughput prediction method of activity for the bioactive substances
| Project/Area Number |
20590046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
KOYAMA Junko Kobe Pharmaceutical University, 薬学部, 准教授 (60102109)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Norihiro 神戸薬科大学, 薬学部, 教授 (90205477)
MORITA Izumi 神戸薬科大学, 薬学部, 助手 (20299085)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 分析化学 / 生物活性物質 |
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| Research Abstract |
The biochemical activities (anti-promoter of tumor, anti-bacterial, anti-inflammatory, and anti-allergic activities) of quinones, flavonoids, lignans, and alkaloids were determined. Good correlation was found between the activities and the oxidation-reduction potentials by a cyclic voltammetry. It was thought that elucidating the generality of these correlations enabled a prediction of the bioactivity of compound by the physical measurement without in vitro assay. As for the result, the oxidation-reduction potential was suggested that it was a good parameter.
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[Journal Article] Geranyl Derivatives of Isoquinoline Alkaloids Show Incresed Biologycal Activities2010
Author(s)
Yumi Nishiyama, Kinuko Iwasa, Suguru Okada, Sousuke Takeuchi, Masataka Moriyasu, Miyoko Kamigauchi, Junko Koyama, Atsuko Takeuchi, Harukuni Tokuda, Hye-Sook Kim, Yusuke Wataya, Kazuyoshi, Takeda, Yi-Nan Liu, Pei-Chi Wu, Kenneth F.Bastow, Toshiyuki Akiyama, Kuo-Hsiung Lee
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Journal Title
HETEROCYCLES 81
Pages: 1193-1229
Peer Reviewed
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[Journal Article] Biotransformation of Phenolic Tetrahydroprotoberbe-rines in Plant Cell Cultures Followed by LC-NMR, LC-MS, and LC-CD2010
Author(s)
Kinuko Iwasa, Wenhua Cui, Teturo Takahashi, Yumi Nishiyama, Miyoko Kamigauchi, Junko Koyama, Atsuko Takeuchi, Masataka Moriyasu, Kazuyoshi Takeda
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Journal Title
J.Nat.Prod. 73
Pages: 115-122
Peer Reviewed
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