2010 Fiscal Year Final Research Report
Organelle selective targeting of ABC subfamily D proteins and molecular mechanisms of their functions on the membranes
| Project/Area Number |
20590054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
IMANAKA Tsuneo University of Toyama, 大学院・医学薬学研究部(薬学), 教授 (50119559)
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| Co-Investigator(Kenkyū-buntansha) |
KASHIWAYAMA Yoshinori 富山大学, 大学院・医学薬学研究部(薬学), 助教 (20401812)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ABCタンパク質 / ペルオキシソーム / 小胞体 / 局在化機構 / 基質輸送機構 / 脂肪酸輸送 / Pex19p / Pex3p |
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| Research Abstract |
We found that the hydrophobic properties of NH_2-terminal cytosolic region of ABC subfamily D proteins determine their subcellular localization. ABC proteins (ABCD1～3) with the NH_2-terminal hydrophobic region are targeted to peroxisomes through the interaction of ABCD1～3 to Pex19p and Pex3p. On the other hand, ABCD4 without the hydrophobic region is targeted to endoplasmic reticulum. Concerning function of ABC subfamily D proteins, ABCD1～3 are suggested to be involved in transport to acyl-CoA and ABCD4 is involved in heme metabolism.
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