2010 Fiscal Year Final Research Report
Production of hepatocyte growth factor (HGF) and tissue regeneration induced by natural products
| Project/Area Number |
20590058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
GOHDA Eiichi Okayama University, 大学院・医歯薬学総合研究科, 教授 (20028814)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肝細胞増殖因子(HGF) / 細胞増殖 / ニガウリ / 冬虫夏草 / ポリミキシンB |
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| Research Abstract |
Hepatocyte growth factor (HGF) has been shown to stimulate the proliferation of epithelial cells in various tissues including hepatocytes and play critical roles in regenerative events of tissues. Here we found that the extracts of bitter melon placenta and Cordyceps sinensis and polymyxin B promoted HGF production in human fibroblasts and described their mechanism and properties of active component(s). Injection of polymyxin B to rats significantly increased both plasma and hepatic HGF levels.
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