2010 Fiscal Year Final Research Report
The structure and function of new drug excreting transporter "MATE" in mannmal.
| Project/Area Number |
20590059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
OOTSUKA Masato Okayama University, 自然生命科学研究支援センター, 准教授 (30243489)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生化学 / 薬物排出 / 輸送体 / 有機カチオン / 薬物副作用軽減 |
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| Research Abstract |
There are so many transporters in kidney and these transporters are concerned about transepithelial transport. These transporters don't work alone but may be working together. From this idea, drug excretion is precisely controlled and these should be well organized mechanism. MATE transporter is also controlled with these mechanism. In MATE transporter, there is long tail in C-terminus region, so, in this region should hove some function for regulation. From this hypothesis, several functional proteins are identified.
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