2010 Fiscal Year Final Research Report
Construction of a Bank of the Cells Lacking Phosphoinositide-Metabolizing Enzymes
| Project/Area Number |
20590060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
HAZEKI Osamu Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (80142751)
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| Project Period (FY) |
2008 – 2010
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| Keywords | イノシトールリン脂質代謝 / shRNA / RAW264.7細胞 / ファゴサイトーシス / ファゴソーム / PtdIns(3)P / eGFP-FYVE |
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| Research Abstract |
A series of cells lacking phosphoinositide-metabolizing enzymes was prepared from RAW264.7 macrophages. The analysis with the cells identified a group of enzymes functioning in phagocytotic events. Selective inhibitors of phosphoinositidemetabolizing enzymes are attractive candidates for medicines such as anti-cancer drugs. The bank of the cells can be used to determine the specificity of the inhibitors.
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Research Products
(17 results)
