2010 Fiscal Year Final Research Report
Regulation of the onset of atopic asthma-like phenotype by microorganisms (virus-mimetics)
| Project/Area Number |
20590062
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
TANAKA Hiroyuki Gifu Pharmaceutical University, 薬学部, 准教授 (70264695)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アレルギー / 気管支喘息 / ウィルス / 微生物 |
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| Research Abstract |
In the present study, we examined the effect of intratracheal administration of double-stranded RNA (dsRNA), produced during virus replication, prior to the repeated instillation of mite extract into the airways on the development of asthma-like phenotypes by in mice. As a result, a lower amount of dsRNA augmented the onset of asthma-like phenotypes, whereas a higher dose of dsRNA inhibited the development of the pathophysiological changes. These effects by dsRNA are dependent of CD8+T cells and IL-13 or CD8+T cells and IFN-g, respectively. Furthermore, we demonstrated that these modifications by dsRNA were not dependent on TLR3, TLR4 or MDA-5.
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