Regulatory mechanism of the induction and function of IL-1

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590064
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: ONOZAKI Kikuo Nagoya City University, 大学院・薬学研究科, 教授 (20101313)
• Project Period (FY): 2008 – 2010
• Keywords: IL-1 / 化学物質 / タバコ / 関節リウマチ / 炎症性サイトカイン / 性ホルモン / 自己免疫

Research Abstract

(1) The mechanism of constitutive production of IL-1α : For the constitutive production of IL-1α in human melanoma cells down-regulation of HDAC1 activity and up-regulation of Sp1 activity appeared to be important. (2) Regulation of IL-1 function by sex hormone : Dihydrotestosterone inhibited the proinflammatory cytokine production in human synovial fibroblast cells through hormone receptor-mediated down-regulation of NF-κB activity. (3) Regulation of IL-1 production by chemicals : Cigarette smoke condensate induced proinflammatory cytokines from RA patient-derived synovial cells, and augmented the development of collagen-induced arthritis in mice.

Research Products

• [Journal Article] Etiological role of cigarette smoking in rheumatoid arthritis : Nasal exposure to cigarette smoke condensate extracts augments the development of collagen-induced arthritis in mice. (2011)
  • Author(s): Okamoto S, Adachi M, Chujo S, Yamada K, Akita K, Itoh S, Takii T, Hayakawa K, Onozaki K.
  • Journal Title: Biochem Biophys Res Commun. 404(4) Pages: 1088-1092
• [Journal Article] Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. (2011)
  • Author(s): Horita Y, Takii T, Kuroishi R, Chiba T, Ogawa K, Kremer L, Sato Y, Lee Y, Hasegawa T, Onozaki K.
  • Journal Title: Bioorg Med Chem Lett. 21(3) Pages: 899-903
• [Journal Article] Effectiveness of BCG vaccination to aged mice (2010)
  • Author(s): Ito T, Takii T, Mitsuo Maruyama M, Daisuke Hayashi D, Takeshi Wako T, Azusa Asai A, Yasuhiro, Horita Y, Taniguchi K, Yano I, Yamamoto S, Onozaki K
  • Journal Title: Immunity & Ageing 7 Pages: 12-15
• [Journal Article] Cigarette smoke condensate extracts augment collagen-induced arthritis in mice. (2010)
  • Author(s): Chujo S, Okamoto S, Sunahara R, Adachi M, Yamada K, Hayashi H, Taakii T, Hayakawa K, Onozaki K
  • Journal Title: Int Immunopharmacol. 10(10) Pages: 1194-1199
• [Journal Article] Dual mode of regulation of cell division cycle 25 A protein by TRB3. (2010)
  • Author(s): Sakai S, Ohoka N, Onozaki K, Kitagawa M, Nakanishi M, Hayashi H.
  • Journal Title: Biol Pharm Bull. 33(7) Pages: 1112-1116
• [Journal Article] Biochemical characteristics among Mycobacterium bovis BCG substrains. (2010)
  • Author(s): Hayashi D, Takii T, Mukai T, Makino M, Yasuda E, Horita Y, Yamamoto R, Fujiwara A, Kanai K, Kondo M, Kawarazaki A, Yano I, Yamamoto S, Onozaki K
  • Journal Title: FEMS Microbiol Lett. 306(2) Pages: 103-109
• [Journal Article] Halophilic beta-lactama as a new solubility-and folding-enhancing tag protein : production of native human interleukin 1 alpha and human neutrophil alpha-defensin. (2010)
  • Author(s): Tokunaga H, Saito S, Sakai K, Yamaguchi R, Katsuyama I, Arakawa T, Onozaki K Arakawa T, Tokunaga M.
  • Journal Title: Appl Microbiol Biotechnol. 86(2) Pages: 649-658
• [Journal Article] IL-1-induced ERK1/2 activation up-regulates p21(Waf1/Cip1) protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A375. (2010)
  • Author(s): Arakawa T, Hayashi H, Itoh S, Takii T, Onozaki K
  • Journal Title: Biochem Biophys Res Commun. 392(3) Pages: 369-372
• [Journal Article] Anaphase-promoting complex/cyclosomecdh 1 mediates the ubiquitination and degradation of TRB3. (2010)
  • Author(s): Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H.
  • Journal Title: Biochem Biophys Res Commun. 92(3) Pages: 289-294
• [Journal Article] Staphylococcal superantigen-like protein 10 (SSL10) binds to human immune-Globulin G(IgG) and inhibits complement activation via the classical pathway. (2010)
  • Author(s): Itoh S, Hamada E, Kamoshida G, Yokoyama R, Takii T, Onozaki K, Tsuji T.
  • Journal Title: Mol Immunol. 47(4) Pages: 932-938
• [Journal Article] Etiological and biological aspects of cigarette smoking in rheumatoid arthritis. (2009)
  • Author(s): Onozaki K.
  • Journal Title: Inflamm Allergy Drug Targets. 8(5) Pages: 364-368
• [Journal Article] Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis (2009)
  • Author(s): Horita Y, Takii T, Chiba T, Kuroishi R, Maeda Y, Kurono Y, Inagaki E, Nishimura K, Yamamoto Y, Abe C, Mori M, Onozaki K.
  • Journal Title: Bioorg Med Chem Lett. 15;19(22) Pages: 6313-6316
• [Journal Article] An environmental sensor, TRPV4 is a novel regulator of intracellular Ca^<2+> in human, synoviocytes. (2009)
  • Author(s): Itoh Y, Hatano N, Hayashi H, Onozaki K, Miyazawa K, Muraki K.
  • Journal Title: Am J Physiol Cell Physiol. 297(5) Pages: C1082-C1090
• [Journal Article] Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) substrains. (2009)
  • Author(s): Hayashi D, Takii T, Fujiwara N, Fujita Y, Yano I, Yamamoto S, Kondo M, Yasuda E, Inagaki E, Kanai K, Fujiwara A, Kawarazaki A, Chiba T, Onozaki K.
  • Journal Title: FEMS Immunol Med Microbiol. 56(2) Pages: 116-128
• [Journal Article] Population is a Critical Factor for Global Carbon Dioxide Increase. (2009)
  • Author(s): Onozaki K
  • Journal Title: J. Health Sci. 55(1) Pages: 125-127
• [Journal Article] Inhibition of Human Immunodeficiency Virus Type 1 Replication by Blocking I{kappa}B Kinase with Noraristeromycin. (2008)
  • Author(s): Asamitsu K, Yamaguchi T, Nakata K, Hibi Y, Victoriano AF, Imai K, Onozaki K, Kitade Y, Okamoto T.
  • Journal Title: J.Biochem. 144(5) Pages: 581-589
• [Journal Article] Cigarette smoke condensate up-regulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line. (2008)
  • Author(s): Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y, Takii T, Koshiko M, Chung SW, Hayakawa K, Miyazawa K, Hirose K, Onozaki K.
  • Journal Title: J.Interferon Cytokine Res. 28 Pages: 509-522
• [Journal Article] Contribution of extracellular signal-regulated kinases to the IL-1-induced growth inhibition of human melanoma cells A375. (2008)
  • Author(s): Arakawa T, Yamamura T, Hattori T, Hayashi H, Mori A, Yoshida A, Uchida C, Kitagawa M, Onozaki K.
  • Journal Title: Int Immunopharmacol. 8(1) Pages: 80-89
• [Journal Article] The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1α in human melanoma cells. (2008)
  • Author(s): Enya K, Hayashi H, Takii T, Ohoka N, Kanata S, Okamoto T, Onozaki K.
  • Journal Title: J.Leuk.Biol. 83(1) Pages: 190-199
• [Presentation] マウス関節炎の発症増強作用を示すタバコ成分に関する研究 (2011)
  • Author(s): 秋田邦彦, 岡本翔佑, 中条里美, 足達実季, 山田恭平, 伊藤佐生智, 瀧井猛将, 早川和一, 小野嵜菊夫
  • Organizer: 日本薬学会第131回年会 p253
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] タバコ抽出物によるマウス関節炎の増強作用 (2011)
  • Author(s): 足達実季, 岡本翔佑, 中條里美, 山田恭平, 秋田邦彦, 伊藤佐生智, 瀧井猛将, 早川和一, 小野嵜菊夫
  • Organizer: 日本薬学会第131回年会 p253
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] Rheumatoid arthritis patient-derived synoviocytes are more sensitive to cigarette smoke condensate extracts-induced IL-1 beta mRNA expression through NF-・B activation than OA patient-derived synoviocytes (2010)
  • Author(s): 小野嵜菊夫, 岡本翔佑, 伊藤佐生智, 瀧井猛将
  • Organizer: human lung fibroblasts and human lung epithelial cells 14th International Congress of Immunology 2010 PP-036-13
  • Place of Presentation: Kobe, Japan
  • Year and Date: 20100822-20100827
• [Presentation] 男性ホルモンによる関節リウマチ滑膜細胞からの炎症性サイトカインの産生抑制 0P-pm035 (2010)
  • Author(s): 許鍵, 伊藤友香, 瀧井猛将, 林秀敏, 小野嵜菊夫
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-30
• [Presentation] Cigarette smoke condensate extracts induce proinflammatory cytokines from synovial cells and exacerbate collagen-induced arthritis in mice Tri-Society Annual Conference 2009 of the Society for Leukocyte Biology (2009)
  • Author(s): Onozaki K, Chujo S, Okamoto S, Sunahara R, Itoh Y, Hayashi H, Takii T, Hayakawa K
  • Organizer: International Cytokine Society, & International Society for Interferon and Cytokine Research
  • Place of Presentation: Lisbon
  • Year and Date: 2009-11-21