2010 Fiscal Year Final Research Report
Analysis of the functional interactions of factors concerned with histones in malignant transformation.
| Project/Area Number |
20590065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
OSADA Shigehiro Nagoya City University, 大学院・薬学研究科, 准教授 (40263305)
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| Project Period (FY) |
2008 – 2010
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| Keywords | エピジェネティクス / ヒストン / クロマチン / アセチル化 / メチル化 / 発がん / 細胞がん化 / 腫瘍マーカー |
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| Research Abstract |
Mutations in oncogene and tumor suppressor gene lead to malignant transformation. Dysregulation of DNA methylation and histone modification is also found in cancer. Epigenetic studies are also required to understand molecular mechanisms of carcinogenesis and tumorigenesis. Here, we revealed that epigenetics regulatory factors, which induced hepatocarcinogenesis, including histone acetyltransferase, histone methyltransferase, and histone variant, regulated gene expression of tumor marker, cell proliferation, and anchorage-independent growth.
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