2010 Fiscal Year Final Research Report
Characterization and physiological significance of the interaction between mannan-binding protein and matrix metalloproteases.
| Project/Area Number |
20590074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
KAWASAKI Nobuko Ritsumeikan University, 総合理工学研究機構, 教授 (70077676)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Toshisuke 立命館大学, 総合理工学研究機構, 教授 (50025706)
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| Project Period (FY) |
2008 – 2010
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| Keywords | マンナン結合タンパク質 / マンナン結合レクチン / メプリン / マトリックスメタロプロテアーゼ / レクチン / 糖鎖 / 補体活性化 / 腎虚血再灌流 |
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| Research Abstract |
The molecular mechanism of the interaction between a Ca^<2+>-dependent lectin, mannanbinding protein (MBP) and metalloproteases, meprins and its functional roles in the ischemia/reperfusion-operated mouse kidneys were studied.
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Research Products
(22 results)
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[Journal Article] Dendritic cellspecific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) recognizes a novel ligand, Mac-2-binding protein, characteristically expressed on human colorectal carcinomas2011
Author(s)
M.Nonaka, BY.Ma, H.Imaeda, K.Yamaguchi, N.Kawasaki, K.Hodohara, N.Kawasaki, A.Andoh, Y.Fujiyama, T.Kawasaki
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Journal Title
Journal of Biological Chemistry(First Published Online on April 22, 2011) (in press)
Pages: doi:10.1074/jbc.M110.215301
Peer Reviewed
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[Journal Article] Highly Fucosylated N-Glycan Ligands for Mannan-binding Protein Expressed Specifically on CD26 (DPPVI) Isolated from a Human Colorectal Carcinoma Cell Line, SW1116.2009
Author(s)
N.Kawasaki, C-W.Lin, R.Inoue, K-H.Koo, N.Kawasaki, B-Y.Ma, S.Oka, M.Ishiguro, T.Sawada, H.Ishida, T.Hashimoto, T.Kawasaki
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Journal Title
Glycobiology 19
Pages: 437-450
Peer Reviewed
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