2010 Fiscal Year Final Research Report
Construction of an arteriosclerosis assessment system using genetically modified cells and animals, and drug development
| Project/Area Number |
20590078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
OKANO Toshio Kobe Pharmaceutical University, 薬学部, 教授 (20131542)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Kimie 神戸薬科大学, 薬学部, 講師 (90309435)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 分子生物学 / 遺伝子改変細胞 / 遺伝子改変動物 / 動脈硬化モデル / ビタミンD / ビタミンK / 生合成酵素 / 活性評価 |
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| Research Abstract |
To elucidate the role of vitamin D in the prevention and treatment of arteriosclerosis, we have generated vitamin D receptor(VDR) gene knockout mice or vitamin D metabolically activating enzyme, CYP27B1 gene knockout mice together with the cells possessing genetically modified VDR or CYP27B1 gene, and have constructed an assessment system using the above cells and animals. We have found a novel human vitamin K biosynthesis enzyme, UBIAD1 and have constructed an assessment system at cellular level for the elucidation of the role of vitamin K in the prevention and treatment of arteriosclerosis.
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