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2010 Fiscal Year Final Research Report

Molecular Analysis of cognitive impairment associated with postmenopausal memory loss and Alzheimer's disease

Research Project

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Project/Area Number 20590083
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionOsaka University

Principal Investigator

TAKUMA Kazuhiro  Osaka University, 大学院・薬学研究科, 准教授 (90289025)

Project Period (FY) 2008 – 2010
Keywordsアルツハイマー病 / 更年期障害 / エストロゲン / 海馬 / ミトコンドリア / コリン作動性神経系 / 神経変性
Research Abstract

Estrogen decline after menopause may influence cognitive performance and increase risk for Alzheimer's disease (AD) in women. We have previously found that combination of chronic stress and ovariectomy (OVX) causes memory impairment in mice. In this study, we found that cholinergic neuronal loss in the hippocampal CA3 region is involved in OVX/stress-induced memory impairment in mice, and donepezil and galantamine, which are clinically used for AD therapy, improved the memory impairment.

  • Research Products

    (11 results)

All 2011 2010 2009 2008

All Journal Article (7 results) Presentation (4 results)

  • [Journal Article] Nicotine ameliorates impairment of working memory in methamphetamine-treated rats2011

    • Author(s)
      Hiroyuki Mizoguchi, Daisuke Ibi, Fumiaki Takase, Taku Nagai, Hiroyuki Kamei, Erika Toth, Jun Sato, Kazuhiro Takuma, Kiyofumi Yamada
    • Journal Title

      Behav.Brain Res. 220(1)

      Pages: 159-163

  • [Journal Article] Alterations of emotional and cognitive behaviors in matrix metalloproteinase-2 and -9-deficient mice2010

    • Author(s)
      Hiroyuki Mizoguchi, Daisuke Ibi, Kazuhiro Takuma, Erika Toth, Jun Sato, Shigeyoshi Itohara, Toshitaka Nabeshima, Kiyofumi Yamada
    • Journal Title

      Open Behav.Sci.J. 4

      Pages: 19-25

  • [Journal Article] Aβトランスポーター2010

    • Author(s)
      田熊一敞 片岡駿介, 吾郷由希夫, 松田敏夫
    • Journal Title

      脳21 13

      Pages: 59-62

  • [Journal Article] RAGE-mediated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction2009

    • Author(s)
      Kazuhiro Takuma, Fang Fang, Wensheng Zhang, Shiqiang Yan, Emiko Fukuzaki, Heng Du, Alexander Sosunov, Guy McKhann, Yoko Funatsu, Noritaka Nakamichi, Taku Nagai, Hiroyuki Mizoguchi, Daisuke Ibi, Osamu Hori, Satoshi Ogawa, David M.Stern, Kiyofumi Yamada, Shirley ShiDu Yan
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106(47)

      Pages: 20021-20026

  • [Journal Article] ミトコンドリア障害と神経系のアポトーシス~アルツハイマー病解明へのアプローチ~2009

    • Author(s)
      田熊一敞, 片岡駿介, 吾郷由希夫, 松田敏夫
    • Journal Title

      日本薬理学雑誌 134(4)

      Pages: 180-183

  • [Journal Article] Matrix metalloprotease-9 inhibition improves amyloid β-mediated cognitive impairment and neurotoxicity in mice2009

    • Author(s)
      Hiroyuki Mizoguchi, Kazuhiro Takuma, Emiko Fukuzaki, Daisuke Ibi, Eiichi Someya, Ko-hei Akazawa, Tursun Alkam, Hiroko Tsunekawa, Akihiro Mouri, Yukihiro Noda, Toshitaka Nabeshima, Kiyofumi Yamada
    • Journal Title

      J.Pharmacol.Exp.Ther. 331(1)

      Pages: 14-22

  • [Journal Article] Ovariectomy increases serum amyloid β peptide and hippocampal ABAD levels in mice2008

    • Author(s)
      Emiko Fukuzaki, Kazuhiro Takuma, Yoko Funatsu, Yukiko Himeno, Yuko Kitahara, Hiroyuki Mizoguchi, Daisuke Ibi, Koji Koike, Masaki Inoue, Shi Du Yan, Kiyofumi Yamada
    • Journal Title

      Nuerochem.Int. 52(7)

      Pages: 1358-1364

  • [Presentation] 糖化最終産物受容体を介するアミロイド神経毒性発現とその薬物標的としての可能性2011

    • Author(s)
      田熊一敞, 松田敏夫, 山田清文
    • Organizer
      第84回日本薬理学会年会シンポジウム
    • Place of Presentation
      大会中止のため誌上開催
    • Year and Date
      2011-02-15
  • [Presentation] Mitochondria-mediated neurotoxicity in Alzheimer's disease.2010

    • Author(s)
      田熊一敞, 松田敏夫
    • Organizer
      第37回日本トキシコロジー学会学術年会シンポジウム
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2010-06-17
  • [Presentation] ミトコンドリア障害と神経系のアポトーシス ~アルツハイマー病解明へのアプローチ~2009

    • Author(s)
      田熊一敞, 片岡駿介, 吾郷由希夫, 松田敏夫
    • Organizer
      第82回日本薬理学会年会シンポジウム
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-03-16
  • [Presentation] Role of receptor for advanced glycation endproducts in neuronal amyloid β-peptide membrane transport2008

    • Author(s)
      Kazuhiro Takuma, Emiko Fukuzaki, Yoko Funatsu, David M.Stern, 山田清文, Shi Du Yan
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease (ICAD2008)
    • Place of Presentation
      McCormick Place, Chicago, IL, USA.
    • Year and Date
      2008-07-30

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Published: 2012-01-26   Modified: 2016-04-21  

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