2010 Fiscal Year Final Research Report
Sp3 and its regulatory effect of gene expression provide new insights to treat chronic obstructive pulmonary disease.
| Project/Area Number |
20590084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
ISOHAMA Yoichiro Kumamoto University, 大学院・生命科学研究部, 准教授 (10240920)
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| Co-Investigator(Renkei-kenkyūsha) |
HISATSUNE Akinori 熊本大学, 大学院・生命科学研究部, 助教 (50347001)
KATSUKI Hiroshi 熊本大学, 大学院・生命科学研究部, 教授 (40240733)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肺胞上皮細胞 / アクアポリン / 転写因子Sp3 |
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| Research Abstract |
In this study, we examined the role of Sp3 in alveolar cells, during differentiation. We have found that Sp3 is expressed in alveolar type II cells and mesenchymal cells, but not in type I cells, and that overexpression of Sp3 considerably increased mRNA expression of an enzyme, which is important to synthesis pulmonary surfactant. In addition, Sp3 may be involved in IL-6- and STAT3-dependent gene expression. Further, expression of Sp3 and aquaporin-3 was decreased by TNF-alpha, through the activation of ERK and CEBP.
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[Journal Article] A selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8mRNA expression in oleic acid-induced lung injury in guinea pigs.2009
Author(s)
Ishitsuka Y, Moriuchi H, Isohama Y, Tokunaga H, Hatamoto K, Kurita S, Irikura M, Iyama K, Irie T.
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Journal Title
J Pharmacol Sci. 111
Pages: 211-215
Peer Reviewed
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[Journal Article] Age-related pulmonary emphysema in mice lacking alpha/beta hydrolase domain containing 2 gene.2009
Author(s)
Jin S, Zhao G, Li Z, Nishimoto Y, Isohama Y, Shen J, Ito T, Takeya M, Araki K, He P, Yamamura K.
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Journal Title
Biochem Biophys Res Commun. 380
Pages: 419-424
Peer Reviewed
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