2010 Fiscal Year Final Research Report
Study on the mechanism underling development of neurodegenerative diseases with age-related dysfunction of the endoplasmic reticulum
| Project/Area Number |
20590095
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Yokohama College of Pharmacy |
|---|
Principal Investigator |
TOMOBE Koji Yokohama College of Pharmacy, 薬学部, 講師 (80460286)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NOMURA Yasuyuki 横浜薬科大学, 薬学部, 教授 (00034041)
KANEKO Masayuki 千葉科学大学, 薬学部, 講師 (10322827)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 老化 / 老化促進マウス / 酸化ストレス |
|---|
| Research Abstract |
In this study, we investigated the mechanism underling the development of accelerated senescence in SAMP8 mice. Oxidative stress is a cause of aging, and is systemically accumulated in SAMP8. Thus, we estimated Nrf2, oxidative stress sensor, in the liver of SAMP8 and SAMR1 by Western Blot analysis. The protein level of Nrf2 in the nucleus of the liver was significantly decreased in SAMP8. In addition, the phosphorylation of Akt and GSK-3b was significantly decreased in the liver of SAMP8. Thus, it is suggested that the reduction of the translocation of Nrf2 into the nucleus might be induced by a decrease of GSK-3b phosphorylation, resulting in an increase of oxidative stress in SAMP8 mice.
|
