2010 Fiscal Year Final Research Report
Role of lymphocytic cholinergic system in regulation of fat metabolism
| Project/Area Number |
20590096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
FUJII Takeshi Doshisha Women's College of Liberal Arts, 薬学部, 准教授 (80255380)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATORI Yuki 同志社女子大学, 薬学部, 助教 (90411090)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWASHIMA Koichiro 武蔵野大学, 薬学研究所, 客員教授 (70095008)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アセチルコリン / リンパ球 / 肥満 / コリンアセチルトランスフェラーゼ / ムスカリン受容体 / ニコチン受容体 |
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| Research Abstract |
We investigated the involvement of non-neuronal cholinergic system in lymphocytes in fat metabolism. Acetylcholine (ACh) production, activity and mRNA expression of choline acetyltransferase (ChAT), an ACh-synthesizing enzyme, in ob/ob mice, an animal model of type 2 obese diabetes, is reduced when compared with that of control (lean) mice. Lymphocytic cholinergic activity increased with age. These findings suggest that lymphocytic cholinergic system is involved in regulation of fat metabolism.
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