2010 Fiscal Year Final Research Report
Study on effects of Helicobacter pylori infection on expression and function of proteinase-activated receptors in gastric mucosal epithelium.
| Project/Area Number |
20590097
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
SEKIGUCHI Fumiko Kinki University, 薬学部, 准教授 (90271410)
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| Co-Investigator(Kenkyū-buntansha) |
KAWABATA Atsufumi 近畿大学, 薬学部, 教授 (20177728)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 薬理学 |
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| Research Abstract |
In the cancer area of gastric mucosal epithelium from gastric cancer patients, we found a tendency that expression of proteinase-activated receptor-1 (PAR1) was positively correlated with infection levels of Helicobacter pylori (H. pylori), suggesting involvement of increased expression of PAR1 in the development of H. pylori-related gastric cancer. We also determined if H. pylori might possess PAR-activating proteinases in various cell lines. However, we did not find any proteinases that activate PAR1, PAR2 or PAR4, in the H. pylori extracts.
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