2010 Fiscal Year Final Research Report
The change of DNA repair enzymes and nucleoside transoprters by oxydative stress in astrocytes
| Project/Area Number |
20590098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
TANAKA Koh-ichi Hyogo University of Health Sciences, 薬学部, 助教 (30274848)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIYAMA Nobuyoshi 兵庫医療大学, 薬学部, 教授 (20201692)
SATO Tomoaki 鹿児島大学, 大学院・医歯学総合研究科, 教授 (10284887)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アストロサイト / 酸化ストレス / 過酸化水素 / DNA修復酵素 / DNAポリメラーゼβ / ヌクレオシド輸送体 / CNT / ENT |
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| Research Abstract |
The investigation of the mechanisms occurring the diseases on the central nervous system and the treatment are one of the important subjects, when an aging society would have continued. In this research we studied the influence with DNA injury that reactive oxygen species, which are related with a lot of the diseases on the central nervous system and have many affecting mechanisms that have not understood. We made clear that the mechanisms of nucleoside transporters, which transport substrates of DNA repair material, are related with the function of DNA repair enzymes and made important roles.
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