2011 Fiscal Year Final Research Report
Design and development of antigene agents based on strand invasion mechanism
| Project/Area Number |
20590099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUGIYAMA Toru 東京大学, 大学院・総合文化研究科, 助教 (40242036)
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| Co-Investigator(Kenkyū-buntansha) |
KITTAKA Atsushi 帝京大学, 薬学部, 教授 (00214833)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 核酸 / ゲノム / 遺伝子 / 癌 / 有機化学 |
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| Research Abstract |
Peptide nucleic acid (PNA) is a synthetic nucleic acid mimic in which the sugar phosphate backbone is replaced by a peptide backbone. In this study, we proposed a concept of topological stabilization of PNA-DNA hybrid duplexes and demonstrated the validity of the concept. Furthermore, cooperative triplex invasion and sequence-specific cleavage of DNA have also been achieved.
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