2010 Fiscal Year Final Research Report
Development of zinc chelators to inhibit function of zinc protein participating in invasion and metastasis of cancer cell
| Project/Area Number |
20590104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
OKAMOTO Yoshinari Kumamoto University, 大学院・生命科学研究部, 助教 (20194409)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKA Masami 熊本大学, 大学院・生命科学研究部, 教授 (40126008)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 癌 / 浸潤・転移 / 亜鉛キレーター |
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| Research Abstract |
Recently, it has been reported that transcription factor Snail, protease ADAM10 and ADAM17 are participating in invasion and metastasis of cancer cell. The present study aimed at development of specific inhibitors of these proteins. We are successful to synthesis a new pyridine/cysteamine based zinc chelator equipped with a marimastat side chain. This compound showed 80% inhibition against focus formation in 20 mM without any cell toxicity.
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[Journal Article] Properties and Synthesis of 2-{2-Fluoro (or Bromo)-4-[(2-oxocyclo pentyl)methyl]phenyl}propanoic acid : Nonsteroidal Antiinflmmatory Drugs withLow Membrane Permeabiliz- ing and Gastric Lesion-Producing Activities2010
Author(s)
Naoki Yamakawa, Shintaro Suemasu, Masaaki Matoyama, Ayumi Kimoto, Miho Takeda, Ken-ichiro Tanaka, Tomoaki Ishihara, Takashi Katsu, Yoshinari Okamoto, Masami Otsuka, Tohru Mizushima
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Journal Title
J. Med. Chem. Vol.53
Pages: 7879-7882
Peer Reviewed
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[Journal Article] Accerelated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles2009
Author(s)
Tsutomu Ishihara, Miho Takeda, Haruka Sakamoto, Ayumi Kimoto, Chisa Kobayashi, Naoko Takasaki, Kanae Yuki, Ken-ichiro Tanaka, Mitsuko Takenaga, Rie Igarashi, Taishi Maeda, Naoki Yamakawa, Yoshinari Okamoto, Masami Otsuka, Tatsuhiro Ishida, Hiroshi Kiwada, Yutaka Mizushima, Tohru Mizushima
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Journal Title
Pharmaceut. Res. Vol.26
Pages: 2270-2279
Peer Reviewed
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[Journal Article] Synthesis of prostagrandin E1 phosphate derivatives and their encapsulation in biodegradable nanoparticle2009
Author(s)
Miho Takeda, Taishi Maeda, Tsutomu Ishihara, Haruka Sakamoto, Kanae Yuki, Naoko Takasaki, Fumihiro Nishimura, Takeshi Yamashita, Ken-ichiro Tanaka, Mitsuko Takenaga, Rie Igarashi, Megumu Higaki, Naoki Yamakawa, Yoshinari Okamoto, Hisao Ogawa, Masami Otsuka, Yutaka Mizushima, Tohru Mizushima
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Journal Title
Pharmaceut. Res. Vol.26
Pages: 1792-1800
Peer Reviewed
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