Involvement of Oxidized Phospholipids in Aberrant Expression of Adipocytokines

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590105
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Kumamoto University
• Principal Investigator: KUNIYASU Akihiko Kumamoto University, 大学院・生命科学研究部, 准教授 (90241348)
• Project Period (FY): 2008 – 2010
• Keywords: 医薬分子機能学

Research Abstract

In obesity, oxidative stress is involved in aberrant production of adipocytokines. We found that oxidized LDL enhances the productions of plasminogen activator inhibitor-1 and resistin, and their molecular mechanism includes the production of reactive oxygen species followed by ERK signaling activation. Taken together, anti-oxidant reagents or ERK inhibitors may be useful for the prevention and treatment for metabolic syndromes.

Research Products

• [Journal Article] Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression through reactive oxygen species generation and ERK1/2 activation in 3T3-L1 adipocytes (2011)
  • Author(s): Kuniyasu A., Tokunaga T., Yamamoto Y., Inoue S., Obama K., Kawahara K., Nakayama H.
  • Journal Title: Biochim. Biophys. Acta 1811 Pages: 153-162
  • Peer Reviewed
• [Journal Article] Targeting neuropilin-1 in human leukemia and lymphoma. (2011)
  • Author(s): Karjalainen K., Jaalouk D.E., Bueso-Ramos C.E., Zurita A.J., Kuniyasu A., Lichtiger B., O' Brien S., Kantarjian H.M., Cortes J.E., Koivunen E., Arap W., Pasqualini R.
  • Journal Title: Blood 117 Pages: 920-927
  • Peer Reviewed
• [Journal Article] Interconversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5a receptor by a single amino acid substitution. (2010)
  • Author(s): Jia, N., Semba, U., Nishiura, H., Kuniyasu, A., Nsiama, T.K., Nishino, N., Yamamoto, T.
  • Journal Title: J. Leukoc. Biol. 87 Pages: 965-975
  • Peer Reviewed
• [Journal Article] Three-dimensional structure of α1-β complex in skeletal muscle dihydropyridine receptor by single particle electron microscopy (2010)
  • Author(s): Murata K., Nishimura S., Kuniyasu A., Nakayama H.
  • Journal Title: J. Electron Microsc. 59 Pages: 215-226
  • Peer Reviewed
• [Journal Article] Contribution of BCR-ABL-independent activation of ERK1/2 to acquired imatinib resistance in K562 chronic myeloid leukemia cells (2010)
  • Author(s): Nambu T., Araki N., Nakagawa A., Kuniyasu A., Kawaguchi T., Hamada A., Saito H.
  • Journal Title: Cancer Sci. 101 Pages: 137-142
  • Peer Reviewed
• [Journal Article] オートファジー誘導に基づく白血病治療薬の開発 (2010)
  • Author(s): 國安明彦
  • Journal Title: 薬事日報「研究戦略・YAKU学-研究現場から臨床へ-」
• [Journal Article] Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain β-amyloid peptides in APP23 mice (2009)
  • Author(s): Kawahara K., Nishi K., Suenobu M., Ohtsuka H., Maeda A., Nagatomo K., Kuniyasu A., Staufenbiel M., Nakagomi M., Shudo K., Nakayama H.
  • Journal Title: Biol. Pharm. Bull. 32 Pages: 1307-1309
  • Peer Reviewed
• [Journal Article] Marked induction of inducible nitric oxide synthase and tumor necrosis factor-α in rat CD40^+ microglia by comparison to CD40 microglia (2009)
  • Author(s): Kawahara K., Yoshida A., Koga K., Yokoo S., Kuniyasu A., Gotoh, T., Sawada M., Nakayama H.
  • Journal Title: J. Neuroimmunol. 208 Pages: 70-79
  • Peer Reviewed
• [Journal Article] Linkage between phosphorylation of the origin recognition complex and its ATP-binding activity in Saccharomyces cerevisiae (2009)
  • Author(s): Makise M., Takehara M., Kuniyasu A., Matsui N., Nakayama H., Mizushima T.
  • Journal Title: J. Biol. Chem. 284 Pages: 3396-3407
  • Peer Reviewed
• [Journal Article] A synthetic approach to develop peptide inhibitors selective for brain-type sodium channels on the basis of pompilidotoxin structure (2009)
  • Author(s): Yokote S., Setoguchi R., Shimizu E., Mishima N., Kawahara K., Kuniyasu A., Shirasaki S., Takahama K., Konno K., Kawai N., Yamaoka K., Kinoshita E., Nakayama H.
  • Journal Title: Heterocycles 79 Pages: 925-933
  • Peer Reviewed
• [Journal Article] オートファジーを誘導するペプチド (2009)
  • Author(s): 國安明彦
  • Journal Title: ケミカルエンジニヤリング 54 Pages: 819-824
• [Journal Article] Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib羊esistance in K562 cells (2008)
  • Author(s): Hirayama C., Watanabe H., Nakashima R., Nanbu T., Hamada A., Kuniyasu A., Nakayama H., Kawaguchi T., Saito H.
  • Journal Title: Pharm. Res. 25 Pages: 827-835
  • Peer Reviewed
• [Journal Article] Combinatorial targeting of the macropinocytotic pathway in leukemia and lymphoma cells (2008)
  • Author(s): Nishimura S., Takahashi S., Kamikatahira H., Kuroki Y., Jaalouk DE., O'Brien S., Koivunen E., Arap W., Pasqualini R., Nakayama H., Kuniyasu A.
  • Journal Title: J. Biol. Chem. 283 Pages: 11752-11762
  • Peer Reviewed
• [Presentation] 分泌性Phospholipase A2によるアディポサイトカイン産生制御 (2009)
  • Author(s): 萱島知子、山田真梨子、國安明彦
  • Organizer: 第26回日本薬学会九州支部大会
  • Place of Presentation: 九州大学(福岡県福岡市)
  • Year and Date: 2009-12-12
• [Presentation] 翻訳活性化を介した酸化LDLによるレジスチン産生促進 (2009)
  • Author(s): 萱島知子, 徳永真理子, 國安明彦, 杉本幸彦, 中山仁
  • Organizer: フォーラム2009衛生薬学・環境トキコロジー
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県宜野湾市)
  • Year and Date: 2009-11-06
• [Presentation] アディポサイトカイン発現におけるホスホリパーゼA2修飾LDLの影響 (2009)
  • Author(s): 國安明彦, 萱島知子, 山田真梨子, 杉本幸彦
  • Organizer: フォーラム2009衛生薬学・環境トキコロジー
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県宜野湾市)
  • Year and Date: 2009-11-05
• [Presentation] アディポネクチン発現におけるリゾホスファチジルコリンの作用 (2008)
  • Author(s): 萱島知子, 國安明彦, 井上祥子
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県神戸市)
  • Year and Date: 2008-12-09
• [Presentation] 脂肪細胞における酸化ストレス誘発性PAI-1分泌の分子機序 (2008)
  • Author(s): 井上祥子, 徳永真理子, 國安明彦, 中山仁
  • Organizer: 第25回日本薬学会九州支部大会
  • Place of Presentation: 九州保健福祉大学(宮崎県延岡市)
  • Year and Date: 2008-12-07
• [Presentation] アディポカイン発現によるリゾホスファチジルコリンの影響 (2008)
  • Author(s): 井上祥子, 國安明彦
  • Organizer: フォーラム2008衛生薬学・環境トキコロジー
  • Place of Presentation: 熊本市国際交流会館(熊本県熊本市)
  • Year and Date: 2008-10-17
• [Remarks] ホームページ等
  • URL: http://square.umin.ac.jp/yseika/