2010 Fiscal Year Final Research Report
Involvement of Oxidized Phospholipids in Aberrant Expression of Adipocytokines
Project/Area Number |
20590105
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Drug development chemistry
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Research Institution | Kumamoto University |
Principal Investigator |
KUNIYASU Akihiko Kumamoto University, 大学院・生命科学研究部, 准教授 (90241348)
|
Project Period (FY) |
2008 – 2010
|
Keywords | 医薬分子機能学 |
Research Abstract |
In obesity, oxidative stress is involved in aberrant production of adipocytokines. We found that oxidized LDL enhances the productions of plasminogen activator inhibitor-1 and resistin, and their molecular mechanism includes the production of reactive oxygen species followed by ERK signaling activation. Taken together, anti-oxidant reagents or ERK inhibitors may be useful for the prevention and treatment for metabolic syndromes.
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[Journal Article] Targeting neuropilin-1 in human leukemia and lymphoma.2011
Author(s)
Karjalainen K., Jaalouk D.E., Bueso-Ramos C.E., Zurita A.J., Kuniyasu A., Lichtiger B., O' Brien S., Kantarjian H.M., Cortes J.E., Koivunen E., Arap W., Pasqualini R.
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Journal Title
Peer Reviewed
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[Journal Article] Interconversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5a receptor by a single amino acid substitution.2010
Author(s)
Jia, N., Semba, U., Nishiura, H., Kuniyasu, A., Nsiama, T.K., Nishino, N., Yamamoto, T.
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Journal Title
J. Leukoc. Biol. 87
Pages: 965-975
Peer Reviewed
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[Journal Article] Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain β-amyloid peptides in APP23 mice2009
Author(s)
Kawahara K., Nishi K., Suenobu M., Ohtsuka H., Maeda A., Nagatomo K., Kuniyasu A., Staufenbiel M., Nakagomi M., Shudo K., Nakayama H.
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Journal Title
Biol. Pharm. Bull. 32
Pages: 1307-1309
Peer Reviewed
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[Journal Article] A synthetic approach to develop peptide inhibitors selective for brain-type sodium channels on the basis of pompilidotoxin structure2009
Author(s)
Yokote S., Setoguchi R., Shimizu E., Mishima N., Kawahara K., Kuniyasu A., Shirasaki S., Takahama K., Konno K., Kawai N., Yamaoka K., Kinoshita E., Nakayama H.
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Journal Title
Heterocycles 79
Pages: 925-933
Peer Reviewed
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[Journal Article] Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib羊esistance in K562 cells2008
Author(s)
Hirayama C., Watanabe H., Nakashima R., Nanbu T., Hamada A., Kuniyasu A., Nakayama H., Kawaguchi T., Saito H.
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Journal Title
Pharm. Res. 25
Pages: 827-835
Peer Reviewed
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[Journal Article] Combinatorial targeting of the macropinocytotic pathway in leukemia and lymphoma cells2008
Author(s)
Nishimura S., Takahashi S., Kamikatahira H., Kuroki Y., Jaalouk DE., O'Brien S., Koivunen E., Arap W., Pasqualini R., Nakayama H., Kuniyasu A.
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Journal Title
J. Biol. Chem. 283
Pages: 11752-11762
Peer Reviewed
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