Search on molecular target cancer drug from microbial secondary metabolites

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590107
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Iwaki Meisei University
• Principal Investigator: KIM Yongpil Iwaki Meisei University, 薬学部・薬学科, 准教授 (70337997)
• Co-Investigator(Kenkyū-buntansha): HAYASHI Masahiko いわき明星大学, 薬学部・薬学科, 教授 (20164965)
• Project Period (FY): 2008 – 2010
• Keywords: 分子標的治療薬 / 微生物二次代謝産物 / HIF-1α / 低酸素

Research Abstract

It aimed at the treatment with high selective effect for cancer, HIF-1α (hypoxic inducible factor-1α) was made a molecular target from microbial secondary metabolites, we obtained a new type lead compounds. We expect that these compounds become a new type anti-cancer drug if anti-cancer mechanism action is clarified in the future.

Research Products

• [Journal Article] Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. I : Fermentation, isolation and biological properties. (2010)
  • Author(s): R. Uchida, M. Iwatsuki, Y.P. Kim, S. Ohte, S. Omura, H. Tomoda
  • Journal Title: J.Antibiotics Pages: 151-155
  • Peer Reviewed
• [Journal Article] TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina. (2009)
  • Author(s): M. Ozawa, T. Etoh, M. Hayashi, K. Komiyama, A. Kishida, A. Ohsaki
  • Journal Title: Bioorg.Med.Chem.Lett. Pages: 234-236
  • Peer Reviewed
• [Journal Article] Cyslabdan, a New Potentiator of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Streptomyces sp. K04-0144 I. Taxonomy, Fermentation, Isolation and Structural Elucidation (2009)
  • Author(s): A. Fukumoto, Y.P. Kim,, A. Matsumoto, Y. Takahashi, K. Shiomi, H. Tomoda S. Omura
  • Journal Title: J.Antibiotics Pages: 1-6
  • Peer Reviewed
• [Presentation] 低酸素下HIF-1αの細胞内蓄積抑制作用を有する化合物の作用機序 (2011)
  • Author(s): 金容必、関寧、江藤忠洋、林正彦、田中晴雄
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 20110000
• [Presentation] 土壌糸状菌由来chaetochromin類の低酸素応答性転写因子HIF-1に対する作用 (2010)
  • Author(s): 関寧、金容必、江藤忠洋、林正彦、田中晴雄
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 20100000
• [Presentation] TLRシグナル伝達阻害物質berkeleyacetal Cの標的分子の解明 (2010)
  • Author(s): 江藤忠洋、金容必、田中晴雄、林正彦
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 20100000
• [Presentation] 土壌由来糸状菌の生産する抗炎症物質berkeleyacetal Cの作用機序に関する研究 (2009)
  • Author(s): 江藤忠洋、金容必、田中晴雄、林正彦
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 20090000