2010 Fiscal Year Final Research Report
Synthesis of new analogues based on fat-soluble vitamins and biological evaluation as therapeutic agents for degenerative disease of the brain
| Project/Area Number |
20590113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
SUHARA Yoshitomo Kobe Pharmaceutical University, 環境科学研究室, 准教授 (30297171)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脂溶性ビタミン / 再生医療 / 脳神経変性疾患 / 治療薬 |
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| Research Abstract |
We focused on vitamin K analogues among fat-soluble vitamins to explore therapeutic agents for degenerative disease of brain. It has been clarified that menaquinone-4 (MK-4), one of the vitamin K homologues, is biosynthesized in a living body and accumulated to the various tissues. MK-4 also protected oligodendrocyte precursors and immature fetal cortical neurons from oxidative injury, independent of the vitamin K-dependent γ-carboxylative reaction. Therefore, MK-4 should play an important role for a living body, especially in brain. On the basis of these findings, we evaluated the biological action of vitamin K homologues with chemical techniques using fluorescent labeled and deuterated labeled analogues. Furthermore, we also synthesized new vitamin K analogues and evaluated biological activities such as their differentiation-inducing activity from stem cells to neuron and gene transcription through the steroid and xenobiotic receptor (SXR).
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