2010 Fiscal Year Final Research Report
Analysis of multidrug resistance systems in multidrug resistant bacteria and development of drugs effective on the resistant bacteria
| Project/Area Number |
20590120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
TSUCHIYA Tomofusa Okayama University, 大学院・医歯薬学総合研究科, 教授 (80012673)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 多剤耐性菌 / 耐性系 / 多剤排出ポンプ / 医薬品開発 / 抗菌薬 / バイオフィルム形成阻害 |
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| Research Abstract |
The worst 1 of cause of human death is infectious disease by pathogenic microorganisms. In developed countries, such as our country and countries in Europe and North America, infectious diseases by multidrug-resistant bacteria are serious problems. Many drugs used at clinical sites are not effective on the multidrug resistant bacteria. Aims of this research are to analyze multidrug resistant systems in multidrug resistant bacteria and to develop drugs effective on such resistant bacteria. In fact, we analyzed multidrug resistant systems in several multidrug resistant bacteria, and found several seed compounds effective on such multidrug resistant bacteria.
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[Journal Article] Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents.2010
Author(s)
Hossion, A.M., N.Otsuka, R.K.Kandahary, T.Tsuchiya, W.Ogawa, A.Iwado, Y.Zamami, K.Sasaki.
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Journal Title
Bioorg.Med.Chem.Lett. 20
Pages: 5349-5352
Peer Reviewed
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