2010 Fiscal Year Final Research Report
Molecular- and structural-biological studies on plant necrosis
| Project/Area Number |
20590123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
MORIMOTO Satoshi Kyushu University, 大学院・薬学研究院, 教授 (60191045)
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| Co-Investigator(Kenkyū-buntansha) |
TAMADA Taro 日本原子力研究開発機構, 研究主幹 (50391248)
TAURA Futoshi 九州大学, 大学院・薬学研究院, 助教 (00301341)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 薬用資源学 |
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| Research Abstract |
Two cannabinoids were identified as plant necrosis-inducing factors from Cannabis sativa. In addition, genes encoding cyclophilin D (CYD) and voltage-dependent anion channel (VDAC), which are assumed to be involved in necrosis, were cloned and expressed in E. coli. Anti-VDAC antibodies were prepared using recombinant VDAC. Animal VDAC antibodies are known to inhibit necrosis in animal cells, whereas the above VDAC antibodies obtained in my study had such inhibitory effect for plant cells.
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