2010 Fiscal Year Final Research Report
Study of glycosidation mechanism of 4'-O-methylpyridoxine in the processing process of Ginkgo biloba seeds and toxicity
| Project/Area Number |
20590124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
WADA Keiji Health Sciences University of Hokkaido, 薬学部, 教授 (40158689)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Teruki 北海道医療大学, 薬学部, 准教授 (60220737)
KOBAYASHI Daisuke 北海道医療大学, 薬学部, 講師 (30405667)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 自然毒食中毒 / 毒性評価 / 配糖体 / 食品加工 / 銀杏中毒 |
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| Research Abstract |
It was reported that 4'-O-methylpyridoxine (MPN) is responsible for Gin-nan food poisoning by our group. In this study, we newly suggested that MPN-5'-glucoside, rather than MPN, is consumed when we eat Ginkgo biloba seeds. Additionally, MPN-5'-glucoside had a lethal effect in mice, as well as MPN. A portion of orally administered MPN-5'-glucoside was directly absorbed and a portion of the other was hydrolyzed to MPN in intestine. This is the first study which suggested contribution of absorption and hydrolysis of MPN-5'-glucoside in intestine to the first step of occurrence of Gin-nan food poisoning.
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