2010 Fiscal Year Final Research Report
Analysis of mode of cytokine secretion in respiratory tracts of influenza-virus infected mice at the early phase of infection.
| Project/Area Number |
20590131
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
MASAHIKO Kurokawa Kyushu University of Health and Welfare, 薬学部, 教授 (80186527)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Wataru 九州保健福祉大学, 薬学部, 教授 (50399218)
SHIMIZU Tomomi 九州保健福祉大学, 薬学部, 助教 (80412831)
YOSHIDA Hiroki 九州保健福祉大学, 薬学部, 助教 (90469411)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 微生物 / 感染症学 |
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| Research Abstract |
In the influenza infection, cytokines are produced in respiratory tracts and their production is important in promoting host-immune defense to alleviate symptoms especially in the early stage of infection. Using murine intranasal infection model, we examined the cascade of cytokine production after infection and found that IL-12 was produced by macrophages infiltrating the infected epitherium as the first response cytokine. Also, in influenza virus-infected mice administered 7-hydroxycoumarin that can modulate cytokine production in macrophage-like P388D1 cells, we revealed that the modulation of inflammatory cytokines in the respiratory tracts of infected mice was critical to alleviate influenza symptoms. Thus, it was suggested that the modulators of cytokine production are the candidates of effective anti-influenza agents in alleviation of the symptoms.
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