2010 Fiscal Year Final Research Report
Study on TRP ion channels activation by carbonyl compounds in indoor environments
| Project/Area Number |
20590133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
JINNO Hideto National Institute of Health Sciences, 生活衛生化学部, 第一室長 (10179096)
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| Co-Investigator(Kenkyū-buntansha) |
KAGAWA Toshiko 国立医薬品食品衛生研究所, 生活衛生化学部, 主任研究官 (40188313)
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| Research Collaborator |
OHKAWARA Susumu 武蔵野大学, 薬学部, 講師 (20409387)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 環境衛生学 / シックハウス症候群 / イオンチャネル |
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| Research Abstract |
In order to clarify the mechanism of health problems caused by indoor environments, we established transformants stably expressing the 6 transient receptor potential (TRP) channels, and developed a high throughput assay for the screening the indoor chemicals which activates the TRP ion channels. In this study, we demonstrated that indoor carbonyl compounds such as a limonene oxidation product, 1-methyl-4-acetylcyclohexene activated human TRPA1, which is known to be a sensory neuronal TRP ion channel in airway chemosensation and inflammation.
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