2010 Fiscal Year Final Research Report
Experimental study on effect of Rho kinase inhibitors against neurological impairment by environmental toxins
| Project/Area Number |
20590135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | National Institute for Minamata Disease |
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Principal Investigator |
FUJIMURA Masatake National Institute for Minamata Disease, 基礎研究部, 室長 (20416564)
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| Co-Investigator(Kenkyū-buntansha) |
USUKI Fusako 国立水俣病総合研究センター, 臨床部, 室長 (50185013)
IZUMO Shuji 鹿児島大学, 医学部, 教授 (30143811)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 中毒学 |
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| Research Abstract |
We mainly show that inhibition of the Rho kinase pathway prevents MeHg-intoxication. 2 Rho kinase inhibitors, Fasudil and Y-27632, significantly protected against axonal degeneration and apoptotic cell death in cultured cortical neuron exposed to MeHg. Fasudil also prevented the neuronal degeneration in peripheral nerves and hind limb crossing sign in MeHg-intoxicated model rats. Furthermore, Rho kinase inhibitors were effective for axonal degeneration and cell death in cultured cortical neuron exposed to inorganic mercury or Rotenone as a candidate substance responsible for Parkinson disease.
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