2010 Fiscal Year Final Research Report
Role of ileal bile acid absorption on regulation of serum cholesterol levels
| Project/Area Number |
20590137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
MIYATA Masaaki Tohoku University, 大学院・薬学研究科, 助教 (90239418)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHINARI Kouichi 東北大学, 大学院・薬学研究科, 准教授 (60343399)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ASBT / コレステロール / 胆汁酸 / FXR / 腸内細菌 / 抗菌薬 |
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| Research Abstract |
Intestinal bile acid absorption is negatively regulated through cholesterol signaling in an FXR-independent manner. Intestinal bile acid absorption is also regulated through enterobacteria-mediated bile acid transformation.
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