2010 Fiscal Year Final Research Report
Mechanisms of female-specific expression of drug-metabolizing enzyme CYP3A : comparison between human and mouse
| Project/Area Number |
20590140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
SAKUMA Tsutomu University of Toyama, 大学院・医学薬学研究部(薬学), 准教授 (30250468)
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| Co-Investigator(Kenkyū-buntansha) |
NEMOTO Nobuo 富山大学, 大学院・医学薬学研究部(薬学), 教授 (10085631)
KAWASAKI Yuki 富山大学, 大学院・医学薬学研究部(薬学), 助教 (30432107)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 薬物代謝酵素 / CYP3A / 発現制御 / 性差 / マウス |
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| Research Abstract |
To clarify the molecular mechanisms of female-dominant expression of drug-metabolizing enzyme CYP3As in the liver, we analyzed the mechanisms of female-specific expression of mouse Cyp3a41 gene. Our results indicated that HNF4α plays an important role in the transcriptional activation of the Cyp3a41 gene, and a sex difference in chromatin structure may contribute to the female-specific expression of Cyp3a41 in the livers of mice.
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