2010 Fiscal Year Final Research Report
Development of anti-oxidizing therapy of NASH using inhibitors of NADPH oxidase
| Project/Area Number |
20590141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
MIYAMOTO Ken-Ichi Kanazawa University, 附属病院, 教授 (30100514)
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| Project Period (FY) |
2008 – 2010
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| Keywords | NASH / NADPHオキシダーゼ / 酸化ストレス / 炎症 / 肝線維化 |
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| Research Abstract |
It is suggested that butylic acid activates AMP-activated protein kinase (AMPK) and inhibits histone deacetylase (HDAC) thereby improves lipid metabolism in the liver by activating lipid β-oxidation. S. reticulata extract exhibited anti-obesity effect by increasing serum adiponectin and enhancing lipid metabolism. P. flos extract exhibited anti-obesity effect through an action on the liver and brown fat cell. These findings may facilitate clarification and treatment of non-alcoholic steatohepatitis (NASH).
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[Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance.2010
Author(s)
Hirofumi Misu, Toshinari Takamura, Hiroaki Takayama, Hiroto Hayashi, Naoto Matsuzawa-Nagata, Seiichiro Kurita, Kazuhide Ishikura, Hitoshi Ando, Yumie Takeshita, Tsuguhito Ota, Masaru Sakurai, Tatsuya Yamashita, Eishiro Mizukoshi, Taro Yamashita, Masao Honda, Ken-ichi Miyamoto, Tetsuya Kubota, Naoto Kubota, Takashi Kadowaki, Han-Jong Kim, In-kyu Lee, Yasuhiko Minokoshi, Yoshiro Saito, Kazuhiko Takahashi, Yoshihiro Yamada, Nobuyuki Takakura, Shuichi Kaneko.
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Journal Title
Cell Metabolism 12
Pages: 483-495
Peer Reviewed
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[Journal Article] Dose dependent development of diabetes mellitus and non-alcoholic steatohepatitis in monosodium glutamate-induced obese mice.2009
Author(s)
Yoshiyuki Sasaki, Wataru Suzuki, Tsutomu Shimada, Seiichi Iizuka, Satoko Nakamura, Mitsunobu Nagata, Makoto Fujimoto, Koichi Tsuneyama, Ryoji Hokao, Ken-ichi Miyamoto, Masaki Aburada.
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Journal Title
Life Sci. 85(13-14)
Pages: 490-498
Peer Reviewed
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[Journal Article] Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity.2008
Author(s)
Naoto Matsuzawa-Nagata, Toshinari Takamura, Hitoshi Ando, Seiji Nakamura, Seiichiro Kurita, Hirofumi Misu, Tsuguhito Ota, Masayoshi Yokoyama, Masao Honda, Ken-ichi Miyamoto, Shuichi Kaneko.
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Journal Title
Metabolism 57
Pages: 1071-1077
Peer Reviewed
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