Appropriate use of the oral fluoropyrimidine anticancer drugs in patients with colorectal cancer

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590144
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: NISHIGUCHI Kohshi Kyoto Pharmaceutical University, 薬学部, 教授 (80379437)
• Co-Investigator(Kenkyū-buntansha): SAKAEDA Toshiyuki 京都大学, 薬学部, 教授 (00304098) ; HIRAI Midori 神戸大学, 医学部附属病院, 教授 (70228766) ; MINAMI Hironobu 神戸大学, 医学部附属病院, 教授 (60450574) ; TAMURA Takao 近畿大学, 医学部附属病院, 准教授 (80324929) ; YAMAMORI Motohiro 武庫川女子大学, 薬学部, 講師 (10444613)
• Project Period (FY): 2008 – 2010
• Keywords: 大腸癌 / がん化学療法 / フッ化ピリミジン系 / 代謝拮抗剤 / 適正使用

Research Abstract

In the patients with advanced colorectal cancer, pharmacokinetic evaluation was performed to assess whether constant exposure to 5-FU in FOLFIRI regimen was achieved by repetitive oral UFT, and clinical outcome was evaluated. In this study, the incidence of dose-limiting toxicity was almost the same as for FOLFIRI regimen. Pharmacokinetic evaluation suggested continuous exposure to 5-FU by means of repetitive oral UFT administration. However, the bolus injection of 5-FU was thought to be necessary to ensure the efficacy in the chemotherapeutic regimen with repetitive oral UFT.

Research Products

• [Journal Article] Effect of dose-escalation of 5-fluorouracil on circadian variability of its pharmacokinetics in Japanese patients with Stage III/IVa esophageal squamous cell carcinoma. (2010)
  • Author(s): Akiko Kuwahara, Motohiro Yamamori, Kohshi Nishiguchi, Tatsuya Okuno, Naoko Chayahara, Ikuya Miki, Takao Tamura, Kaori Kadoyama, Tsubasa Inokuma, Yoshiji Takemoto, Tsutomu Nakamura, Kazusaburo Kataoka, Toshiyuki Sakaeda
  • Journal Title: Int.J.Med.Sci. 7 Pages: 48-54
  • Peer Reviewed
• [Journal Article] Molecular changes to HeLa cells on continuous exposure to SN-38, an active metabolite of irinotecan hydrochloride. (2009)
  • Author(s): Kohji Takara, Noriaki Kitada, Eri Yoshikawa, Kazuhiro Yamamoto, Sayo Horibe, Toshiyuki Sakaeda, Kohshi Nishiguchi, Noriaki Ohnishi, Teruyoshi Yokoyama
  • Journal Title: Cancer Lett. 278 Pages: 88-96
  • Peer Reviewed
• [Journal Article] Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma. (2009)
  • Author(s): Akiko Kuwahara, Motohiro Yamamori, Kohshi Nishiguchi, Tatsuya Okuno, Naoko Chayahara, Ikuya Miki, Takao Tamura, Tsubasa Inokuma, Yoshiji Takemoto, Tsutomu Nakamura, Kazusaburo Kataoka, Toshiyuki Sakaeda
  • Journal Title: Int.J.Med.Sci. 6 Pages: 305-311
  • Peer Reviewed
• [Journal Article] Three-dimensional, but not two-dimensional, culture results in tumor growth enhancement after exposure to anticancer drugs. (2008)
  • Author(s): Chiho Komoto, Tsutomu Nakamura, Nobuko Ohmoto, Hironao Kobayashi, Tatsurou Yagami, Kohshi Nishiguchi, Koichi Iwaki, Akiko Kuwahara, Motohiro Yamamori, Noboru Okamura, Katsuhiko Okumura, Toshiyuki Sakaeda
  • Journal Title: Kobe J.Med.Sci. 53 Pages: 335-343
  • Peer Reviewed
• [Presentation] 5-FU並びに抗腫瘍性白金錯体に対する感受性規定因子の探索 (2010)
  • Author(s): 濱口良平, 高良恒史, 峯垣哲也, 辻本雅之, 栄田敏之, 西口工司
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] 大腸癌細胞での抗腫瘍性白金錯体及び5-FUの感受性を規定する要因の探索 (2010)
  • Author(s): 峯垣哲也, 高良恒史, 濱口良平, 藪田直希, 辻本雅之, 西口工司
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] 網羅的遺伝子発現解析に基づいた抗腫瘍性白金錯体感受性因子の探索 (2009)
  • Author(s): 藪田直希, 高良恒史, 峯垣哲也, 北田徳昭, 辻本雅之, 西口工司, 横山照由
  • Organizer: 第19回日本医療薬学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2009-10-25
• [Presentation] 抗癌剤調製におけるシリンジによる測定誤差について (2008)
  • Author(s): 多田恵理、打保裕子、藤田恵、丸上奈穂、山道俊彦、山本麻央、堂下真梨、和田敦、角山香織、槇本博雄、西口工司、平井みどり
  • Organizer: 第18回日本医療薬学会年会
  • Place of Presentation: 札幌
  • Year and Date: 2008-09-20